Researchers in SciImmunology have discovered three subsets of macrophages in mice with unique life cycles and origins residing in multiple tissues.
). Likewise, at least three macrophage subpopulations are found within steady-state adipose tissue and intestine, including one resembling TLF). Thus, by understanding that a common substructure exists, we may make direct comparisons between studies.
While a universal framework that is fully conserved across mammalian tissues would provide a simplified and ideal model, the reality is more complex, with nuanced similarities and some exceptions, which we bring to light here. The present study establishes a restricted number of biological commonalities in 17 murine organs. Whether this system is conserved in different organs beyond those we have investigated remains unknown.
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