A new class of immunotherapy drugs – used to treat arthritis, psoriasis, and inflammatory bowel disease – might also work for those with severe asthma.
' because they inhibit the protein JAK1. This protein plays an essential role in the body's immune response by activating cytokines, which can then lead to inflammation.In cases of asthma, however, the JAK1 protein can cause a cytokine 'storm' to develop in the lung, leading to a level of inflammation that can be life-threatening.
Whether this can reduce asthmatic symptoms outside the lab remains to be seen, but it's worth investigating further. Naturally produced by our bodies, the molecule itaconate is already known to play a major role in modifying the behavior of white blood cells. This latest study has uncovered how itaconate and one of its derivatives, 4-octyl itaconate shuts down the JAK1 protein so it can no longer trigger storms of circulating cytokines.
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