Patients with cancer who also have HIV are often excluded from clinical trials, so there is a paucity of data on how ICIs work in this particular patient population.
Patients with cancer who also have HIV are often excluded from clinical trials, so there is a paucity of data on how immune checkpoint inhibitors work in this particular patient population.
The team identified 390 patients with HIV and cancer who had received at least one dose of an immune checkpoint inhibitor, and 70% received anti-PD-1/anti-PD-L1 monotherapy.The most common cancer types among the patients were non-small cell lung cancer in 28% of cases, hepatocellular carcinoma in 11% of cases, and head and neck squamous cell carcinoma in 10% of cases.
Of note, 30% of people with HIV who were treated with ICIs had baseline CD4+ T-cell counts less than 200 cells/µL — and the incidence of irAEs was similar in those patients and in patients with baseline CD4+ T-cell counts greater than 200 cells/µL.An additional analysis compared the effects of ICIs in a cohort of 61 patients with HIV and metastatic NSCLC with a cohort of 110 matched controls who did not have HIV.
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