Imperial researchers have filmed, for the first time, the activity of bodily 'pressure sensors' whose discoverers won the 2021 Nobel Prize in Physiology or Medicine.
. DOI: 10.1038/s41467-023-40134-y
Responsible for detecting and responding to changes in pressure, Piezo channels play a crucial role in regulating blood pressure, respiration, bladder control, and the immune system. The channels could therefore be important future drug targets for diseases including cancer.activity could only be done by invasive or indirect techniques, such as monitoring general calcium fluctuations in cells.
"Piezo1 is involved in many systems that are vital for life. Our visualizations could be instrumental in revealing the full power of Piezo1 activity in different cellular contexts." Once the activity of the channels in disease is better understood, they could be targets for a new non-chemical drug type that works mechanically to complement more widely-used drugs.
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