Moderna vs. Pfizer: Is it OK to mix and match the updated COVID-19 booster shots?

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Moderna vs. Pfizer: Is it OK to mix and match the updated COVID-19 booster shots?
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Do you need to stick with the same brand, or is it safe to mix it up?

LOS ANGELES — As residents prepare to roll up their sleeves for a third, fourth or even fifth dose of COVID-19 vaccine, some may be wondering: Do I need to stick with the same brand, or is it safe to mix it up?

“The best booster for you is the one that you can get — either the Pfizer or the Moderna can be used, and they can be mixed or matched,” said Dr. Robert Kim-Farley, epidemiologist and infectious disease expert at the UCLA Fielding School of Public Health. “If there’s shortages of one, you should not have hesitancy to take the other.”

“It’s OK to mix and match Moderna and Pfizer,” Dr. Ralph Gonzales, associate dean for clinical innovation and chief innovation officer for UC San Francisco, said at a campus town hall last week. “I just got my Moderna two days ago and it was an interesting experience. I definitely felt a stronger response with the Moderna — having had Pfizer before — but either combinations are fine.”

When some people — those age 50 and up and the immunocompromised — became eligible for a second conventional booster shot earlier this year, some decided to go with the other brand. Dr. Robert Wachter, chair of the UC San Francisco Department of Medicine, in April decided to go with Moderna for his fourth shot after three consecutive Pfizers.The updated omicron bivalent booster shot is available to those age 12 and up.

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