Scripps Research scientists are able to pinpoint potential new drug targets by analyzing the effects of mirror image versions of small molecules on clusters of proteins. Scientists from Scripps Research Institute have devised an innovative technique to identify small molecules capable of modifyin
The team plans to use their new approach to study different cell types and discover chemical compounds that impinge upon any readout in the future.
In recent years, Cravatt’s lab has designed sets of small chemicals that can irreversibly bind to certain parts of proteins. However, screening these chemical libraries to discover their possible impact on protein function was generally a slow and tedious process. Since individual proteins have different roles in cell biology, researchers often have to develop specialized functional screens for each protein of interest.
The research team designed pairs of “mirror image” molecules, called stereoisomers, that could each bind irreversibly to proteins in the same way that their previous chemical libraries had worked. The pairs of stereoisomers let them be sure that the impact of each small molecule was due to its unique structure .
In both cases, the new chemicals represent the first time scientists have been able to target the protein complexes— PA28 and the so-called spliceosome— with small, simple synthetic chemicals.
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