Long COVID Patients Respond Differently to COVID Vaccines

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Long COVID Patients Respond Differently to COVID Vaccines
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A new study shows that people with long COVID respond differently to COVID vaccines and that the condition may be caused by a dysfunction of the immune system.

April 27, 2023 – A new study shows that people with long COVID respond differently to COVID vaccines and that the condition may be caused by a dysfunction of the immune system -- possibly explaining why some people experience symptoms for months while others recover and resume normal lives.

The long COVID group also showed an extra immune response that tried to fight the virus in a secondary way that researchers didn’t expect. Both groups showed an initial increase in their blood of antibodies that primarily target what’s known as the “spike” protein of the coronavirus, which allows the virus to invade healthy cells. But the long COVID group also showed a prolonged increased immune response that tried to fight the part of the virus related to how it replicates.

Le is co-director of the COVID-19 Recovery Program at Cedars-Sinai Medical Center in California, where the study was conducted.

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