Across half a century, researchers have deepened their understanding of the causes of psoriasis, which affects more than 125 million people globally.
[A team of dermatologists] discovered that cyclic AMP levels in psoriasis lesions are significantly lower than in healthy skin.… [The team] is now trying to find out if the cyclic AMP deficiency causes psoriasis and to develop a medication to increase cyclic AMP levels in psoriasis lesions.Psoriasis, which affects 2 to 3 percent of the global population, is an inflammatory skin disease marked by red, scaly patches that itch or burn.
Low levels of cyclic AMP — a chemical messenger key to cellular communication — haven’t been found to cause the disease. Psoriasis stems from an overactive immune response.alongside other chemical messengers and immune cells, and certain gene variants can make a person more susceptible. The choice among a range of treatment options today depends in part on the severity of the disease and the areas of the body affected. One drug, called apremilast, approved by the U.S.
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