One researcher said the discovery highlights the need to develop universal vaccines for sarbecoviruses in general.
Coronavirus or SARS-CoV-2 or COVID-19 virusA team led by researchers from Washington State University’s Paul G. Allen School for Global Health has discovered a virus in a Russian bat similar to the virus behind COVID-19 that is “likely capable of infecting humans” and would be resistant to current vaccines, according to a news release.
The researchers found that spike proteins from the bat virus, which is called Khosta-2, can infect human cells and are resistant to monoclonal antibodies and serum from individuals vaccinated against SARS-CoV-2, the virus behind COVID-19.
According to Letko, the discovery of Khosta-2 highlights the need to develop universal vaccines for sarbecoviruses in general, rather than just known variants of COVID-19. “Unfortunately, many of our current vaccines are designed for specific viruses we know infect human cells or those that seem to pose the biggest risk to infect us. But that is a list that’s ever-changing,” Letko said. “We need to broaden the design of these vaccines to protect against all sarbecoviruses.”
When the Khosta-1 and Khosta-2 viruses were originally discovered in Russian bats in late 2020, it was thought that they posed no threat to humans. But researchers learned that, like SARS-CoV-2, Khosta-2 can use its spike protein to infect cells by attaching to a receptor protein found throughout human cells.
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