Recent research and anecdotes suggest some people are testing negative on rapid tests even after they have symptoms, then later testing positive. Here's what researchers think is going on.
, a microbiologist at Yale School of Public Health and one of the authors of that study.
What's different now is that with omicron, many people seem to be coming down with symptoms earlier on in an infection — before tests detect a positive case. Anecdotal reports abound of people showing symptoms of COVID-19 and testing negative at first, before eventually testing positive. "This is all theoretical," Lam stresses, but one idea is that people who are vaccinated start fighting off the infection as soon as it occurs."And even though the virus may actually be living in the patient's nose, the immune system might already be fighting it off, such that the viral load at that point in time of testing is too low to be detectable on the test," he says.
Another idea is that maybe some sub-variants of omicron produce fewer antigens — the proteins on the surface of the coronavirus that rapid tests detect — and that would make the tests less sensitive. To find out if omicron or some of its sub-variants produce less antigen, Lam's team measures patients' antigen levels.Whenever patients test positive, the researchers genetically sequence their virus sample to figure out whether different omicron cases are genetically different.
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