Surviving chemotherapy activates a program of immune checkpoints that protect breast cancer cells from various forms of attack by the immune system. Cancer therapies have made significant progress, and as a result, many forms of breast cancer have a high chance of being treated successfully, part
Breast cancer is a type of cancer that develops in the breast tissue. It is one of the most common types of cancer among women worldwide. Breast cancer can occur in both men and women, however, it is rare in men. Early signs and symptoms of breast cancer include a lump or thickening in the breast tissue, changes in the shape or size of the breast, and changes in the skin of the breast, such as dimpling or redness.
However, the most challenging cases, those that cannot be treated with hormone or targeted therapies and do not respond to chemotherapy, are still the most deadly and difficult to treat.researchers have, for the first time, uncovered how these cancers persist after chemotherapy and why they do not respond well to immunotherapies, which aim to eliminate remaining tumor cells by activating the immune system.
“We’re among the first to actually study the tumor that survives post-chemotherapy, which is called the residual disease, to see what kind of immunotherapy targets are expressed,” said the study’s first author Ashkan Shahbandi, an MD/Ph.D. student in Jackson’s lab.
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