Revamped COVID-19 vaccines are poised to do battle with the super-contagious omicron variant.
,” Peter Marks, director of the FDA’s Center for Biologics Evaluation and Research, which oversees vaccines, said in a news briefing August 31.
Both companies have tested vaccines based on the omicron BA.1 variant in humans. But BA.1, which caused the massive surge earlier in the year, is no longer circulating in the United States. As of the week of August 21 through 27, BA.5 was projected to cause about“This gives us a variant that is most up-to-date, and most likely looks closer to something that may evolve further in the fall,” Marks said.
Bivalent vaccines perform better — raising antibody levels higher in people and animals — than ones that contain just the original spike protein or only a variant spike protein, Miller said. The spike protein that grabs onto human cells is a three-pronged claw. With the bivalent vaccine, each prong could be either an original or an omicron version. The mixed claw may expose parts of the spike to the immune system that are normally hidden, Miller suggested.
Although the content of the vials is different, the new bivalent booster shots, like these made by Pfizer, will need the same storage and handling as the old jabs.Though the mouse data suggest the BA.4/5 booster will work, some of the CDC advisers said they’d be more comfortable having data from the ongoing human clinical trials before recommending the new shots.
The wait could cost lives and money, computer projections suggest. The COVID-19 scenario modeling hub, a consortium of pandemic forecasters who predict COVID-19 patterns over the next six months under varying conditions, considered what would happen in the United States if the boosters were given in September or not until November. Waiting would lead to
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