What Are Zombie Cells and How Are They Linked to Aging?
, M.D., a primary care doctor at Mercy Personal Physicians, explains. But, as you get older, your immune system doesn’t have as large of a capacity to do this.Zombie cells simply stick around in your body. “They don’t die—they become resistant to death,” says researcher Paul Robbins, Ph.D., associate director of the Institute on the Biology of Aging and Metabolism and the Medical Discovery Team on the Biology of Aging at the University of Minnesota. “They stay in your body forever.
However, Dr. Robbins says, senescence is seen as an anti-cancer mechanism because it stops cells that may have become abnormal from continuing to replicate.“I would hypothesize that yes, everyone has these cells,” Dr. Robbins says. “Your burden of cells increases with age and older people or people with chronic diseases may have more.”
Landmark research from Jan van Deursen, Ph.D., of the Mayo Clinic actually removed zombie cells from living mice. Van Deursen and his team, the team found that treating mice to remove zombie cells extended their median lifespans by 17% to 42%, depending on the mice’s sex, diet, and genetic background. The mice that were treated also usually looked healthier than those that weren’t treated and were more likely to have spontaneous activity and explore things—signs of youth.
“If one of these things are affected, the others are, too,” Dr. Robbins says. “They’re all linked.” Meaning, if you can target and wipe out zombie cells, your metabolism and energy may improve, he says.
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