UTSW researcher part of team that’s awarded $36 million heart research grant.
is the founding chair of the department and directs the Hamon Center for Regenerative Science and Medicine and the Wellstone Center for Muscular Dystrophy Research. He holds the Robert A. Welch Distinguished Chair in Science and the Annie and Willie Nelson Professorship in Stem Cell Research.He has spent his career investigating heart and muscle development and disease, leading to his participation on the CureHeart team.
The project will use gene-editing technology CRISPR to complete base and prime editing in the heart for the first time. It can also help the heart produce enough proteins to function normally, again by fixing or stimulating the faulty gene. The researchers believe it could also be successful in preventing the disease from being expressed if inherited. Children who receive the faulty gene from their parents could receive the injection and never develop cardiomyopathy in the first place.
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