COVID infection alters the gut microbiome, allowing harmful bacteria to enter the bloodstream and increasing the risk for potentially life-threatening bloodstream infections, new research suggests. MedTwitter
"Our findings suggest that coronavirus infection directly interferes with the healthy balance of microbes in the gut, further endangering patients in the process," microbiologist and cosenior author Ken Cadwell, PhD, New York University Grossman School of Medicine, New York City, adds in a news release."Now that we have uncovered the source of this bacterial imbalance, physicians can better identify those coronavirus patients most at risk of a secondary bloodstream infection.
In line with their observations in mice, they found that the SARS-CoV-2 infection is associated with"severe microbiome injury," characterized by the loss of gut microbiome diversity. This migration could be due to a combination of the immune-compromising effects of the viral infection and the antibiotic-driven depletion of commensal gut microbes, the researchers say.bacteremia
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