“If our cells acquire too many mutations, it can lead to the development of cancer as well as help the cancer evolve.” usask
Scientifically known as apolipoprotein B mRNA editing enzyme catalytic polypeptides , and with actions detected in many types of cancers, including breast, lung, and ovarian, medical researchers such as University of Saskatchewan PhD candidate Lai Wong are on a mission to understand the role of APOBEC proteins in DNA mutations.We deliver the local news you need in these turbulent times on weekdays at 3 p.m.
Wong said that APOBEC proteins cannot be judged for their cancer risk using the same biological markers as other proteins, making APOBECs an interesting subject for researchers. Supervised by U of S College of Medicine professor Dr. Linda Chelico , Wong’s work involves developing and optimizing experiments that can be used to study the effects of APOBECs on cancer caused by mutations.Article content
“If we can determine what effects APOBECs have on cancer initiation and progression, we may be able to use these proteins to find a drug to block cancer initiation or to suppress cancer evolution during therapy,” Wong said.“I am interested in pursuing a career in clinical research because I’d like to be involved in testing the efficacy and safety of treatments in clinical trials,” she said.
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