ProstateCancer risk stratification based on family history + inherited polygenic risk can better identify men at highest risk of dying from prostate cancer at an early age, new data suggest. OncTwitter
Prior research has suggested that polygenic risk scores outperform family history in predicting prostate cancer risk.
The researchers followed 10,120 male participants from the Health Professionals Follow-up Study who had been genotyped as a part of multiple nested case-control studies, including a prostate cancer case-control study of 2000 case patients and control persons. Compared with men at lowest genetic risk for prostate cancer — those in the bottom polygenic risk score quartile who had no family history — those in the highest genetic risk — the top quartile with a family history of prostate or breast cancer — had nearly a sevenfold increased risk for prostate cancer and a 4.84 increased risk for prostate cancer death.
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