The development of smart biologics has been stuck in the same paradigm - until now. A new startup Pearl Bio is rewriting the language of life with its genetically recoded organism.
Isaacs and Jewett, Pearl Bio’s other Co-founder and Science Advisor, were working on the bleeding edge of synthetic biology at that time: “I was recoding genomes, and Michael was engineering ribosomes. We realized that when you put those two technologies together, you have the ability to basically repurpose the genetic code and the translational machinery of any cell to produce entirely new materials,” says Isaacs.
“This is something that we've been incubating over many years: developing the technology, de-risking proof of concept, and filing IP,” says Isaacs. “With platform technology companies, you want to be poised to advance product development from day one.” gives Pearl Bio the exclusive license for engineering programmable biologics by encoding synthetic chemistries and now brings their total patent figures to 24.describing the first GRO was published in 2013, the technology and the strain were released publicly. But just like the first version of iOS, there were many things that needed to be improved to make the strain better suited for commercial applications.
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