When babies in the African countries of Guinea Bissau and Uganda were given the tuberculosis vaccine, something remarkable happened.
Australian researchers have now pinpointed the biological mechanism behind the off-target effects of the tuberculosis vaccine.
The researchers took blood samples from the infants and examined circulating white blood cells called monocytes in both groups. In vaccinated babies, the BCG vaccine reprogrammed or 'trained' monocytes to be more responsive to pathogens in general, and this epigenetic signature was passed down to the next generation of monocytes for more than a year after vaccination., this is the mechanism behind the broad, protective effect of BCG vaccines seen in African countries.
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