Researchers have made eggs from the cells of male mice — and showed that, once fertilized and implanted into female mice, the eggs can develop into seemingly healthy, fertile offspring
With these tools in hand, Hayashi and his colleagues embarked on a project to create eggs using cells taken from an adult male mouse. They reprogrammed these to create stem-cell-like induced pluripotent stem cells. The team grew these cells in culture until some of them had spontaneously lost their Y chromosome.
The survival rate was low. Out of 630 transferred embryos, only 7 developed into pups. But the pups grew normally and were fertile, Hayashi said at the meeting.The technique is a long way from any kind of medical application. “There are big differences between a mouse and the human,” Hayashi said. Such differences often complicate efforts to translate discoveries in reproductive and stem-cell biology from mice to the clinic.
Another concern is that performing the same technique with human cells might require researchers to grow the egg cells in the laboratory for longer than was necessary with mouse cells, says Mitinori Saitou, a developmental biologist at Kyoto University in Japan who collaborates with Hayashi. “If the culture period becomes longer, then both genetic and epigenetic abnormalities can accumulate,” he told the conference. “The shorter the better.
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