Controlling excess weight could lead to improved health outcomes and slow cognitive decline. A correlation between neurodegeneration in obese people and Alzheimer’s disease (AD) patients has been found in a new study led by scientists at The Neuro (Montreal Neurological Institute-Hospital) of McG
A comparison of cortical thickness between the brains of obese patients to those with Alzheimer’s disease. Darker colors indicate similarities in cortical thickness between the two groups. Credit: Filip MorysA correlation between neurodegeneration in obese people andMcGill University
Previous research has shown that obesity is linked with Alzheimer’s disease -related changes, such as cerebrovascular damage and amyloid-ß accumulation. However, to date, no research has made a direct comparison between brain atrophy patterns in AD and obesity. The scientists found that obesity and AD affected grey matter cortical thinning in similar ways. For example, thinning in the right temporoparietal cortex and left prefrontal cortex were similar in both groups. Cortical thinning may be a sign of neurodegeneration. This suggests that obesity may cause the same type of neurodegeneration as found in people with AD.
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