Scientists have identified the exact point at which healthy brain proteins are shocked into the tangled mess that is commonly associated with Alzheimer's disease.
, tau proteins are suspected to smother neurons from the inside out, interfering with cell function and ultimately leading to cell death.that tau tangles aren't toxic at all, but actually protective in nature, produced in response to some other underlying issue.
This current was designed to mimic the molecular signals that naturally cause 'hyper-folding' of tau proteins in the brain Tau proteins include a group of several soluble variants, but the one used in the current study is called K18, a core peptide containing the microtubule binding domain. Yet even with just 15 minutes of brief exposure, tau proteins began to assemble into knots, albeit ones that were easier to untangle with a reverse voltage.
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