UC Riverside and Yale University team sequences and mines genome of the pathogen Babesia duncani. Scientists have sequenced the genome of Babesia duncani, a pathogen causing the malaria-like disease babesiosis, and identified potential inhibitors for more effective treatments. 'Tis the season
Now a research team led by scientists at the University of California, Riverside, and Yale University reports the first high-quality nuclear genome sequence and assembly of the pathogenPlasmodium falciparum“Our data analysis revealed that the parasite has evolved new classes of multigene families, allowing the parasite to avoid the host immune response,” said Karine Le Roch, a professor of molecular, cell and systems biology at UC Riverside, who co-led the study with Choukri Ben Mamoun, a...
According to Le Roch, who directs the UCR Center for Infectious Disease Vector Research, the study, published today in the journalnot only identifies the molecular mechanism most likely leading to the parasite’s pathogenicity and virulence, but also provides leads for the development of more effective therapies.
A strong immune system is required to fight the pathogen. A compromised immune system could lead to flu-like illness. The tick that spreads babesiosis is mostly found in wooded or grassy areas and is the same tick that transmits bacteria responsible for Lyme disease. As a result, around 20% of patients with babesiosis are co-infected with Lyme disease.mostly infects deer, which serve as the reservoir host during the pathogen’s asexual development.
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