🐭🎧 Scientists successfully reverse hearing loss in mice 🔁👂
New research from The Institute of Psychiatry, Psychology & Neuroscience at King's College London has successfully reversed hearing loss in mice., used a genetic approach to fix deafness in mice with a defectivegene, restoring their hearing abilities in low and middle frequency ranges. Researchers say this proof-of-concept study suggests that hearing impairment resulting from reduced gene activity may be reversible.
Over half of adults in their 70s experience significant hearing loss. Impaired hearing is associated with an increased likelihood of experiencing depression and cognitive decline, as well as being a major predictor of dementia. While hearing aids and cochlear implants may be useful, they do not restore normal hearing function, and neither do they halt disease progression in the ear. There is a significant unmet need for medical approaches that slow down or reverse hearing loss.gene.
Professor Karen Steel, Professor of Sensory Function at King's IoPPN and the study's senior author said,"Degenerative diseases such as progressive hearing loss are often believed to be irreversible, but we have shown that at least one type of inner ear dysfunction can be reversed.
Dr Elisa Martelletti, the study's first author from King's IoPPN said,"Seeing the once-deaf mice respond to sounds after treatment was truly thrilling. It was a pivotal moment, demonstrating the tangible potential to reverse hearing loss caused by defective genes. This groundbreaking proof-of-concept study unlocks new possibilities for future research, sparking hope for the development of treatments for hearing loss.
This study was possible thanks to funding from the Medical Research Council, Wellcome, and from Decibel Therapeutics Inc.
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