'An important step forward.'
As is common in medical research, there are caveats here. We still don't know if the vaccine is able to successfully ward off HIV infection in practice, or how long-lasting any protection might be. Those questions will need to be studied in future clinical trials.
The vaccine candidate, dubbed eOD-GT8 60mer, uses a technique called "germline-targeting," which means that it was designed to induce broadly neutralizing antibodies by stimulating the body's antibody-producing cells. These phase 1 clinical trials started back in 2018, and saw 36 healthy participants aged between 18 and 50 receive two 20-microgram or 100-microgram doses eight weeks apart. A control group of 12 participants received a placebo.
"There's only a few patches on the surface of the HIV spike that remain the same or relatively the same across different isolates," William Schief, author and professor of immunology at Scripps Research,. "And we're trying to elicit very specific antibodies that have very specific properties that allow them to bind to those exact patches."
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