The elixir of life remains the stuff of legend, but aging the young before their time may not be as far-fetched.
In a new experiment, young mice briefly experienced signs of old age when scientists infused them with the blood of older mice. A similar aging effect occurred when human cells were immersed in the plasma of older individuals.
Compared to a control group , the mice that received blood from an old mouse had"decreased maximal twitch force and significantly shorter rates of force development and relaxation during contractions", the researchersThe mice were tested for their physical endurance on a treadmill at baseline and seven days after the blood infusion.
"Using heterochronic blood exchange, we report a transfer of physiologic senescence from old to young mice," the researchersThe researchers hypothesized that cells from older mice were releasing a 'senescence-associated secretory phenotype' that promoted aging, like muscle weakness, loss of endurance, and tissue damage.
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