Model built using human stem cells offers a unique opportunity to study early embryonic development.
, the Gurdon Institute at the University of Cambridge has produced a model human embryo with a heartbeat and some blood that might provide insights into the "black box" stage of life.
Zernicka-Goetz's pioneering work in developing integrated stem cell-derived embryo models has garnered recognition, as she has been named the recipient of the esteemed 2023 Ogawa-Yamanaka Stem Cell Prize. Awarded by Gladstone Institutes and supported by Cell Press, this prize acknowledges her decade-long dedication to research in this field. Her integrated models combine embryonic and extraembryonic stem cells, representing the cells that develop into supporting structures for the growing embryo, such as the placenta and yolk sac.The research team has previously made significant progress in generating mouse embryo-like models from embryonic and extraembryonic stem cells.
While the new human embryo-like models are not as advanced as their mouse counterparts and do not possess beating heart-like structures, they do contain both embryonic and extraembryonic tissues that would typically develop into the placenta, yolk sac, and amnionic sac. The creation of this human embryo-like model represents a significant milestone in our quest to comprehend the complex processes underlying early human development.The human embryo undergoes morphogenetic transformations following implantation into the uterus, yet our knowledge of this crucial stage is limited by the inability to observe the embryo in vivo.
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