It has to do with a thin surface barrier called the glycocalyx.
Cancer cells are notoriously hard to tackle as they hide from the body’s immune system. One way they do this is by forming a thin surface barrier called the glycocalyx.
The glycocalyx is developed with high levels of cell-surface mucins, which are thought to help protect the cancer cell from immune cell attack. However, up to now, there has been limited understanding of this barrier particularly as it relates to cell-based cancer immunotherapies. “We found that changes in the thickness of the barrier that were as small as 10 nanometers could affect the antitumor activity of our immune cells or the engineered cells used for immunotherapy,” said Sangwoo Park, a graduate student in Matthew Paszek’s Lab at Cornell University in Ithaca, New York.
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