Enhancing the Effect of Protein-Based COVID-19 Vaccines Ironically, some vaccines need their own “boosters.” An ingredient called an adjuvant can be added to vaccines to help elicit a more robust immune response, better training the body to fight a pathogen. Scientists report a substance that boost
Researchers developed a substance that boosted the immune response to an experimental COVID-19 shot in mice by 25 times, compared to injection with the vaccine alone.Ironically, some vaccines need their own “boosters.” An ingredient called an adjuvant can be added to vaccines to help elicit a more robust immune response, better training the body to fight a pathogen.
Scientists have discovered that molecules derived from α-galactosylceramide , a compound from marine sponges, can act as adjuvants. They work by stimulating a small population of immune cells that are important for defending the body against viral infections. Rui Luo, Zheng Liu, and their colleagues wanted to see if they could devise a version of αGC to significantly enhance the immune response elicited by a protein-based COVID-19 vaccine.
To measure the effects of the adjuvants, the scientists scrutinized various aspects of immune function, including two ways the immune system eliminates pathogens: through T cells, which kill diseased cells, and antibodies, which are immune proteins that latch onto an invader.
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