Roflumilast Foam Effectively Eases Seborrheic Dermatitis

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Roflumilast Foam Effectively Eases Seborrheic Dermatitis
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After 8 weeks, eight out of ten people with seborrheicdermatitis saw their symptoms cleared or improved with once-daily treatment with roflumilast 0.3% foam, according to the results of the phase 3 STRATUM trial. EADV EADVcongress

It's the same product in both preparations, Blauvelt said during the discussion period."The only major difference between the cream and the foam is the propellant used to make it into a foam. Otherwise, they have the exact same list of ingredients."8-week, double-blind, placebo-controlled trialFor inclusion, patients had to have moderate seborrheic dermatitis, defined as an Investigator's Global Assessment score of three or more.

A 4-point or more improvement in the Worst Itch Numeric Rating Scale — accepted as the minimally clinically important difference — was achieved by more than 60% of patients treated with the foam at week 8, just under 50% at week 4, and just over 30% at week 2. Corresponding rates in the vehicle group were around 40%, 30%, and 15%.

The tolerability findings suggest that the foam vehicle"was an excellent vehicle to be used for this particular drug," with no signs of skin irritation, as rated by patients or investigators."It seems like the vehicle would be a good skincare product for patients," observed the session's cochair,, professor and academic head of the Department of Dermatology at Ghent University Hospital in Belgium.

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