Cancer cells are incredibly adaptable, much like stem cells. Researchers from the University of Basel have discovered substances that artificially mature breast cancer cells of the very aggressive triple-negative subtype and transform them into a state that is similar to normal cells. Cancer occu
To find new ways to treat triple-negative breast cancer, researchers have differentiated cancer cells to convert them into less harmful cells that no longer divide.
Cancer occurs when cells grow uncontrollably and spread to other organs. Cancer cells are quite different from normal ones. Cancer cells are known for their remarkable adaptability to varied settings in the body as well as drug treatments. They resemble stem cells or cells at an early stage of development in this regard.
“We show here that we can convert breast cancer cells to less harmful cells that stop growing,” says Bentires-Alj who is a group leader at the Department of Biomedicine.The hormone estrogen operates as a signaling molecule in cells by attaching to its cognate receptor, the estrogen receptor, inducing a wide range of biological effects. Cells that express the estrogen receptor in the normal breast are mature specialized breast cells that do not proliferate.
The triple-negative breast cancer subtype, however, is not susceptible to estrogens or anti-estrogens. This type of carcinoma occurs mainly in pre-menopausal women and often lacks effective treatment options. “Our initial idea was to induce estrogen receptor expression in order to convert triple-negative breast cancer into estrogen-receptor positive breast cancer because of more effective treatment options available for this subtype,” says the study’s lead author Dr. Milica Vulin.
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