Repairing the eye: Companies are pursuing interventions to edit, regenerate and reprogram eye tissue to restore lost vision
to hit its primary endpoint of corneal repair, it did have statistically significant effects on dryness, burning, stinging and photophobia . Because the vehicle used in the placebo group had antioxidant effects, it could have resulted in a higher than expected response in the control group, Chen said, as well as some effect on stinging. The company aims to move to a phase 3 trial early next year, administering lower volumes of vehicle.
The Wnt signal pathway is important during embryonic development for cellular migration and to determine a cell’s fate, and Endogena observed that its small molecule induced structural and functional improvements in mouse models of RP. Endogena’s co-founder and CEO Matthias Steger says: “We could see an improvement in vision even after three months.” If the program is successful, the company envisages intermittent dosing, to top up the photoreceptor population periodically.
“It’s conceivable that either by tinkering with the sequence of these transcription factors or finding the right combinations that we can get this reprogramming to occur”
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