MitoQ, a publicly accessible dietary supplement that acts as a mitochondrial antioxidant, was discovered through a mouse study to counteract the harmful impacts that HIV and antiretroviral therapy (ART) inflict on the mitochondria within the brain, heart, aorta, lungs, kidney, and liver. The rese
MitoQ, a publicly accessible dietary supplement that acts as a mitochondrial antioxidant, was discovered through a mouse study to counteract the harmful impacts that HIV and antiretroviral therapy inflict on the mitochondria within the brain, heart, aorta, lungs, kidney, and liver.
The research team employed a molecular technique to calculate the proportion between human and murine mitochondrial and nuclear, a key indicator of mitochondrial dysfunction. A decrease in this ratio signals impaired mitochondrial function. Relative to their healthy counterparts, mice infected with HIV and treated with ART demonstrated mitochondrial dysfunction in human immune cells across various organs including the brain, heart, liver, lungs, and gut.
ART itself also affected mitochondrial function in mouse heart cells. When treated with MitoQ for 90 days, HIV-infected mice had reduced mitochondrial dysfunction in organs compared to HIV-infected mice on ART.Mitochondria are the key cell structures that are important for the smooth function of organs such as the brain, heart, liver, and kidney. HIV causes a chronic state of inflammation and immune dysfunction that contribute to organ damage organs.
The researchers note that humanized mice do not exactly recreate HIV infection in humans. Also, the infected mice were exposed to both the virus and the ART and they could not dissect the exact contribution of the virus versus the ART to mitochondrial dysfunction in human cells.These preclinical findings could serve as the foundation for clinical trials in humans with HIV.“MitoQ is a diet supplement that is known to be safe in humans and is readily available for use,” said senior author Dr.
Reference: “Mitoquinone Mesylate and Mitochondrial DNA in End Organs in Humanized Mouse Model of Chronic Treated Human Immunodeficiency Virus Infection” by Sihyeong Song, Sandro Satta, Madhav B Sharma, Cristelle Hugo, Athanassios Kossyvakis, Shubhendu Sen Roy and Theodoros Kelesidis, 24 March 2023,
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