The researchers found a single dose of psilocybin combined with therapy seemed to produce a 'rapid and sustained antidepressant effect' for up to six weeks.
Thursday in the journal JAMA. It involved 104 adults diagnosed with at least moderate clinical depression. The volunteers were randomly assigned to either receive a single 25 milligram dose of psilocybin or niacin, in conjunction with several sessions of therapy. Niacin was chosen as a placebo since it can induce temporary physical sensations like flushed skin, making it harder for volunteers to know which group they belonged to.
The group on psilocybin reported significantly lower levels of depression on average compared to placebo, based on a standard measurement scale. Any observed treatment response also seemed to last longer in those taking psilocybin. And the psilocybin group reported greater improvements in their daily functioning and overall quality of life. People on psilocybin did experience a greater rate of adverse events, but no serious events clearly linked to the treatment were documented, the authors say.
studies continue to suggest that psilocybin-assisted therapy can be a realistic option for some people with depression. A similar Phase II triallast November, for instance, found that people with treatment-resistant depression experienced a significant reduction in symptoms after taking a single large dose of psilocybin along with psychological support.
“These findings add to increasing evidence that psilocybin—when administered with psychological support—may hold promise as a novel intervention” for depression, the authors of this latest
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