Pembrolizumab activity in BCG-refractory papillary bladdercancer GU23 OncTwitter oncology
Poor Prognosis After Relapse on BCG Therapy
Results from cohort A of this study were reported some time ago. This cohort comprised patients with CIS with or without papillary tumors. The clinical complete response rate at 3 months was 40.6%, and the median duration of response was 16 months . This led to regulatory approval in the United States of pembrolizumab for this population.
The median follow-up was 45.4 months; 105 patients discontinued treatment. Of those, 71 patients discontinued treatment because of disease recurrence or progression, and 21 did so because of adverse events. Necchi noted that 22 patients completed the 2 years of treatment; at the time of data cutoff, five patients were receiving treatment.
Treatment-related adverse events occurred in 97 patients . Of these, 19 patients experienced grade 3/4 events . There were no treatment-related deaths, and immune-related and infusion reactions were uncommon.
Argentina Últimas Noticias, Argentina Titulares
Similar News:También puedes leer noticias similares a ésta que hemos recopilado de otras fuentes de noticias.
Chicago business activity gauge sinks further into contractionary territory in FebruaryThe Chicago Business Barometer, also known as the Chicago PMI, sank to 43.6 in February from 44.3 in the prior month, according to ISM-Chicago and MNI.
Leer más »
Paranormal Activity Writer and Director on Future InstallmentsRecurring ParanormalActivity writer and director Christopher Landon thinks the franchise will go on, even if it's without his involvement.
Leer más »
Stacks (STX) surges as Bitcoin NFT hype grows, but its blockchain activity raises concernSTX token staged a near parabolic rally due to the recent hype over Bitcoin NFTs and a protocol upgrade announcement, but there are concerns on whether the ecosystem can gain significant adoption.
Leer más »
China's factory activity bounces further into expansion in FebruaryChina's official manufacturing purchasing managers’ index rose to 52.6 in February – marking the highest reading since April 2012.
Leer más »
China's factory activity stuns with fastest growth in a decadeChina's manufacturing activity expanded as the fastest pace in more than a decade in February, an official index showed on Wednesday, smashing expectations as production zoomed after the lifting of COVID-19 restrictions late last year.
Leer más »
Japan factory activity shrinks the most in 2-1/2 yearsJapan's factory activity shrank in February at the fastest pace in over two years, a private survey showed, highlighting companies' struggles amid a global economic slowdown, raw material inflation and policymakers' calls for higher wages.
Leer más »