Scientists show for the first time that progenitor cell transplantation can reverse the irreversible lung damage caused by COPD even in severe patients.
The study authors recently conducted a phase one trial involving severe COPD patients who were likely to die from the disease. Surprisingly, scientists repaired the damaged lung tissues and improved their condition, using cells from the patient's airways only.
Omar Usmani, a professor of respiratory medicine at Imperial College London who was not involved in the study.The trial involved 20 patients, out of which nine patients suffered from extremely severe COPD, six had severe COPD, two were diagnosed with mild emphysema, and three acted as a control group.
The researchers knew that P63+ cells play an essential role in maintaining and repairing the respiratory tract's epithelial lining, including the airways. When Zuo and his team examined the patients 24 weeks after the experiment, they noticed that various parameters indicatingFor instance, the average diffusion capacity, which shows a healthy air exchange between lungs and blood, rose to 40.3 percent from 30 percent.
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