Obesity Drugs Plus Surgery Add Up to More Weight Loss: Study

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Obesity Drugs Plus Surgery Add Up to More Weight Loss: Study
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Obesity drugs like Wegovy and weight-loss surgery are both effective at helping people lose weight -- what hapens when you combine them?

May 11, 2023 – They’re both popular ways to lose weight. Anti-obesity medications like semaglutide and liraglutide are in such high demand that drugmakers sometimes report shortages. And gastric sleeve surgery – a procedure that shrinks stomach size by up to 80% – remains the most common intervention for weight loss.

Investigators are starting to answer these and other questions that could help the 42% of Americans with obesity. Gastric sleeve surgery was done endoscopically in the study – a minimally invasive procedure known as gastroplasty. Instead of cuts in the stomach, specialists known as bariatric endoscopists insert a flexible tube down the throat and use a special instrument on the end to make the stomach smaller.The combination group took different anti-obesity medications. About one-third took a glucagon-like peptide-1 agonist, or a GLP-1 for short, such as semaglutide and liraglutide.

Not every patient offered weight loss medication is interested, said Jirapinyo, the lead researcher on the study. “Whether you start immediately or wait 3 months afterwards is a question that still needs to be answered,” Austin said.The study is “really exciting and interesting,” said Linda S. Lee, MD, medical director of endoscopy at Brigham and Women’s Hospital.

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