The use of stem cells from umbilical cord blood increases the likelihood of curing HIV for people of all races.
and the "Düsseldorf patient." All three patients received stem cell transplants for their cancer treatments. In each case, the donor cells were obtained from compatible or "matched" adults with two copies of the CCR5-delta32 mutation. This mutation is a natural occurrence that provides resistance to HIV by blocking the virus from entering and infecting cells.
To tackle this potential obstacle for the "New York Patient," the research team transplanted CCR5-delta32/32-carrying stem cells from banked umbilical cord blood, intending to simultaneously treat the patient's cancer and HIV. The team also infused stem cells obtained from a patient's relative along with the umbilical cord blood cells to increase the chance of success.
“Stem cell transplants with CCR5-delta32/32 cells offer a two-for-one cure for people living with HIV and blood cancers,” says expert Deborah Persaud of the Johns Hopkins University School of Medicine.
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