Researchers at Scripps Research examined how the levels of various proteins in brain cells change in response to brain activity. Scripps Research Institute scientists have created a new tool to monitor brain plasticity—the process by which our brains remodel and physically adjust when we learn and
Researchers at Scripps Research have created a novel instrument to monitor brain plasticity.
“We still don’t understand all the mechanisms underlying how cells in our brain change in response to experiences, but this approach gives us a new window into the process,” says Hollis Cline, Ph.D., the Hahn Professor and Chair of Neuroscience at Scripps Research and senior author of the new work. “We wanted to jump into the deep end of the pool and see what proteins are important to brain plasticity,” says Cline.—one of the building blocks of proteins—into one type of neuron at a time. As the cells produced new proteins, they would incorporate this amino acid, azidonorleucine, into their structures. By tracking which proteins contained the azidonorleucine over time, the researchers could monitor newly made proteins and distinguish them from pre-existing proteins.
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