Frequent antibiotics use may increase the risk of developing inflammatory bowel disease for adults over 40, according to research published in the journal Gut. The study suggests that individuals taking antibiotics for gut infections have a higher risk, with the risk being greatest 1-2 years after u
Inflammatory Bowel Disease is a group of chronic disorders that cause inflammation in the digestive tract, including the small intestine and colon. IBD can cause symptoms such as abdominal pain, diarrhea, and weight loss.
One factor associated with IBD risk in younger people is the use of antibiotics, but it’s not clear if this association might also apply to older people. To explore this further, the researchers drew on national medical data from 2000 to 2018 for Danish citizens aged 10 and upwards who hadn’t been diagnosed with IBD.
The risks were slightly higher for Crohn’s disease than they were for ulcerative colitis: 40% among 10-40 year olds; 62% among 40-60 year olds; and 51% among those over 60. The risk seemed to be cumulative, with each subsequent course adding an additional 11%, 15%, and 14% heightened risk, according to the age band.
Nitrofurantoin was the only antibiotic type not associated with IBD risk at any age. Narrow spectrum penicillins were also associated with IBD, although to a much lesser extent. This adds weight to the notion that changes in the gut microbiome may have a key role and that many antibiotics have the potential to alter the makeup of microbes in the gut.
“Furthermore, with repeated courses of antibiotics, these shifts can become more pronounced, ultimately limiting recovery of the intestinal microbiota,” they add.
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