When mice are subjected to sustained, low levels of oxygen similar to those found at an altitude of 4,500 meters, their metabolism changes. In comparison to individuals residing at sea level, the two million individuals worldwide residing at an elevation of 4,500 meters or higher (equivalent to the
A team of scientists in Isha Jain’s lab at Gladstone Institutes showed how chronically low oxygen levels, such as those experienced at 4,500 meters of elevation, rewire how mice burn sugars and fats. Credit: Michael Short/Gladstone Institutes
“When an organism is exposed to chronically low levels of oxygen, we found that different organs reshuffle their fuel sources and their energy-producing pathways in various ways,” says Gladstone Assistant Investigator Isha Jain, Ph.D., senior author of the new study. “We hope these findings will help us identify metabolic switches that might be beneficial for metabolism even outside of low-oxygen environments.
The animals’ metabolism, however, seemed more permanently altered by the hypoxia. For animals housed within the hypoxic cages, blood glucose levels and body weight both dropped, and neither returned to pre-hypoxic levels. In general, these more lasting changes mirror what has been seen in humans who live at high altitudes.
In retrospect, Jain says the observation makes sense; the isolated cells previously studied don’t need to make trade-offs to save glucose, while an entire animal, to survive, does.
Argentina Últimas Noticias, Argentina Titulares
Similar News:También puedes leer noticias similares a ésta que hemos recopilado de otras fuentes de noticias.
New Research Reveals a Simple Way To Reduce Risk of Gestational DiabetesExposure to light for a longer duration just before bedtime increases the likelihood of developing gestational diabetes in pregnant women. According to a new study from Northwestern Medicine, to decrease the chance of developing gestational diabetes mellitus, pregnant individuals should lower the b
Leer más »
China has ramped up construction on its new Antarctic station, new report reveals | CNNChina is making 'significant progress' building the country's fifth research facility in Antarctica after a several years-long lull in construction, according to a report by the Center for Strategic and International Studies (CSIS).
Leer más »
Anemia prevalence among ancient Egyptian child mummies revealed in new researchAnemia in Egyptian kid mummies was studied to find the real reason for their deaths.
Leer más »
1985 Chrysler LeBaron GTS Turbo: Swinging for the FencesFrom the Archive: New car, new suffix, from the New Chrysler Corporation.
Leer más »
Volkswagen reveals the ID.7, new flagship EV with more than 300 miles of rangeVolkswagen's new ID.7 will serve as a flagship for the automaker's growing line of mainstream EVs.
Leer más »
GM reveals Buick Envista as brand's last new gas-powered vehicleThe 2024 Buick Envista will be the brand's last new gas-powered vehicle ahead of its transition to an all-electric domestic lineup by 2030.
Leer más »