Researchers at Karolinska Institute have developed a novel method using DNA nanoballs to detect pathogens, aiming to simplify nucleic acid testing and revolutionize pathogen detection. The study's results, published in Science Advances, could pave the way for a straightforward electronic-based test capable of identifying various nucleic acids in diverse scenarios quickly and cheaply.
Microfluidic chip for impedance-based detection of DNA nanoballs. A photograph of the 3-inch fused silica wafer with six microfluidic devices. Microscopic image of the channel with the integrated gold electrodes. Principle of detection of DNA nanoballs. The passing of a DNA nanoball through the integrated gold electrodes produces a spike signature in the impedance response of the system. This impedance response is recorded as a single DNA nanoball.
"The methodology involves combining Molecular Biology and electronics to yield a pioneering detection tool," says Vicent Pelechano. "Fast and accurate detection of genetic material is key for diagnosis, especially so in response to the emergence of novel pathogens," says Vicent Pelechano. Formation of DNA nanoball using six target-specific LAMP oligos and two compaction oligos. Fluorescence image of DNA nanoballs. Scale bar, 10 μm. Fluorescent image of 1 μM MyOne Dynabeads as size reference. Scale bar, 10 μm. Passive flow of DNA nanoballs in a microfluidic chip made of PDMS on a glass substrate integrated with gold electrodes. The passage of DNA nanoballs through the gold electrodes occludes the current path and disturbs the electric field formed between the gold electrodes.
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