Participants in the trial who took the highest dose of the oral medication saw their blood pressure drop 20 points.
Patients who took a daily dose of the drug, baxdrostat, were able to reduce their blood pressure substantially, compared to a people who got a placebo, according to the study published in the New England Journal of Medicine and presented at the American Heart Association annual meeting on Monday. The new type of oral medication works by targeting a hormone that regulates the amount of salt in the body.in the U.S.
Participants in the phase 2 trial received one of three doses of the new drug or a placebo, along with the medications they were already taking. Those who received the highest dose of the medication saw their— the top number in the measure — drop an extraordinary 20 points during the study. Surprisingly, even the placebo-treated patients saw a reduction of 11 points.
Right now, many with resistant hypertension have to live with the consequences: an increased risk of stroke, heart attack and heart failure. There’s already a medication, spironolactone, that takes aim at the same pathway — that is, lowering the impact of aldosterone, said Lloyd-Jones, who was not involved in the study. That medication blocks the receptor for aldosterone, and while it’s effective it does have side effects, he added.
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