The findings indicate that new antibody therapies must be developed. Are the currently approved antibody therapies used to treat patients who have a higher risk of developing severe COVID-19 disease also effective against the viral variants that are currently in circulation? According to a new stud
Researchers discovered that neither individual antibodies nor antibody cocktails were able to neutralize the Omicron subvariant BQ.1.1.
However, certain SARS-CoV-2 variants, notably the Omicron variant, avoid neutralizing antibodies and cause symptomatic infections even in vaccinated or convalescent individuals due to mutations in the spike protein. This is known as immune evasion, and it poses a hazard to high-risk populations including the elderly and people with weakened immune systems, for example, due to illness or medication.
“For our studies, we mixed non-propagating viral particles carrying the spike protein of selected viral variants with different dilutions of the antibodies to be tested and subsequently measured the amount of antibody needed to inhibit infection of cell cultures. In total, we tested twelve individual antibodies, six of which are approved for clinical use in Europe, and four antibody cocktails” explains Prerna Arora, lead author of the study.
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