COVID-19 booster vaccines targeting the Omicron BA.4 and BA.5 subvariants currently dominating in the United States could be available in the next few days, but their arrival comes with some controversy.
Another potential concern, Topol and others said, is something called imprinting, also known by the catchy but potentially misleading term"original antigenic sin," with a person's first exposure to a virus having an effect on a later response to similar viruses.
Infectious disease expert, William Schaffner, MD, professor of preventive medicine at Vanderbilt University in Nashville, isn't as concerned as others about the lack of human data, citing the need to combat the expected winter surge."If you need a vaccine to combat what some think will be an increase in [cases in] the winter, you won't have an updated vaccine in time if you wait for a clinical trial," he says.
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