European researchers have found a new treatment for advanced melanoma that is more effective than the leading existing therapy.
And while it’s been explored for solid tumors, which make up the majority of cancers, including melanoma, these tumors present challenges that blood cancers do not. Many blood cancers are homogeneous, meaning their cells are uniform. This gives CAR-T therapy a clear target to latch onto and attack. But solid tumors tend to have a number of different cell types that vary largely between cancer types, said Dr.
“We expand them from a million cells to several billion cells,” Dr. John Haanen, a medical oncologist at the Netherlands Cancer Institute, who led the new clinical trial, told NBC News. In the trial, 168 patients with metastatic melanoma were randomly assigned to receive either TIL treatment or the current standard treatment, ancalled ipilimumab. Ipilimumab is typically used in people who don’t respond to a first-line treatment called anti-PD-1 therapy; nearly all of the patients in the trial had not responded to that treatment.
“It’s the first time that we’ve had a result like that with a cell therapy immunotherapy for patients with melanoma,” said Davies, who is on the scientific advisory board for Iovance Biotherapeutics, a California-based company that is conducting aMelanoma rates have been rising rapidly in the United States over the past 30 years, and although metastatic melanoma, the most serious stage of the disease, in which the cancer has spread to other parts of the body, is relatively rare, it’s often...
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