‼️ New assay hailed as a game changer for early Parkinson's Dx MedTwitter NeuroTwitter
Overall, αSyn-SAA differentiated PD from healthy controls with 87.7% sensitivity and 96.3% specificity.Among genetic PD subgroups, sensitivity was highest forAmong clinical features, hyposmia was the most robust predictor of a positive assay result.
Combining genetic and clinical features, the sensitivity of positive αSyn-SAA in sporadic PD with olfactory deficit was 98.6%, compared with 78.3% in sporadic PD without hyposmia. Among those recruited based on their loss of smell, 89% had positive αSyn-SAA results. Similarly, in those with RBD, positive αSyn-SAA results were present in 85% of cases . No other clinical features were associated with a positive αSyn-SAA result.variants but had no PD diagnosis or prodromal symptoms , 9% and 7% , respectively, had positive αSyn-SAA results.
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