For those now grappling with Alzheimer's, lecanemab holds out the promise of slowing the disease's progress. Are the modest benefits worth the risks?
On the heels of anti-amyloid controversy and failures, lecanemab had a lot to prove. But when it comes to its predecessor, Aduhelm,"they're really not comparable," says Karlawish."It's comparing apples and kumquats." The"most compelling difference" between the two drugs, says Wolk, is that the lecanemab trial completed its phase 3 study, with results that suggested"real change" to the course of the disease.
Some experts are skeptical that lecanemab confers much of a benefit at all."A less than half a point difference on an 18-point scale after 18 months of treatment is a rather small effect," Dr. Madhav Thambisetty, a neurologist and a senior investigator at the National Institute on Aging, told Newsweek.
consider the benefits in relation to the side effects. According to the report,"serious adverse events" occurred in 14 percent of participants in the lecanemab group and 11 percent of those in the placebo group. Wolk says this isn't surprising, given that the study followed older adults and reflects data like hospitalizations for other medical conditions. The most commonly reported adverse events were infusion-related reactions.
Karlawish hopes that if the FDA approves the drug, it will require a Risk Evaluation and Mitigation Strategy, a specialized safety protocol that ensures providers of a new drug demonstrate certain knowledge and skills to correctly diagnose, treat and monitor a patient for side effects. Because the U.S.
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