Cerebrovascular insulin receptors are defective in Alzheimer’s disease. A recent study published in the journal Brain conducted by Laval University and Rush University Medical Center has revealed new information about Alzheimer's disease. The study found that the formation of amyloid plaques, one o
disease. The study found that the formation of amyloid plaques, one of the hallmarks of Alzheimer’s disease, is linked to a decrease in insulin receptors in brain microvessels, which may also cause brain insulin resistance.
The research was made possible through a long-term study that started in 1993 and included roughly 1,100 participants from about 30 different American religious congregations. The individuals have agreed to yearly physical and psychological examinations as well as donating their brains after death. Thearticle is based on information from 60 deceased individuals who took part in this extensive study.Insulin receptors are found primarily in blood microvessels, not neurons, as previously thought.
Subjects with fewer alpha-B insulin receptors in their microvessels had more beta-amyloid plaques in their brains.
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