Researchers are gaining new insights into neurological diseases by studying circular RNAs (circRNAs) in brain cells. Investigators found and cataloged mysterious RNA circles that are linked to brain cell identity Findings show that circular RNA is produced by brain cells damaged in Parkinson
Researchers have identified over 11,000 circRNAs in brain cells linked to Parkinson’s and Alzheimer’s. These circRNAs may offer insights into the diseases’ molecular foundations and have potential applications as biomarkers and in RNA-based treatments.
Scherzer and colleagues laser-captured neurons from 190 frozen postmortem human brain samples, including some non-neuronal cells for comparison. Then, they used ultra-deep, total RNA sequencing to study the exact sequences of genetic code found in the circular RNAs within these two cell types. Credit: Clemens Scherzer, Brigham and Women’s Hospitalaser-captured neurons from 190 frozen postmortem human brain samples, including some non-neuronal cells for comparison.
Scherzer and colleagues laser-captured neurons from 190 frozen postmortem human brain samples, including some non-neuronal cells for comparison. Then, they used ultra-deep, total RNA sequencing to study the exact sequences of genetic code found in the circular RNAs within these two cell types. Credit: Clemens Scherzer, Brigham and Women’s HospitalDegeneration of these dopamine and pyramidal neurons plays a key role in the development of neurological disorders.
Nevertheless, the current findings provide the most comprehensive analysis of circRNAs in human brain cells to date and suggest they can be leveraged for RNA diagnostics and medicines used to treat neurological conditions.
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